Acrylonitrile

CAS RN:107-13-1

Carcinogenicity Evidence

Cancer Classification: Group B1 Probable Human Carcinogen

CLASSIFICATION: B1; probable human carcinogen.
BASIS FOR CLASSIFICATION: The observation of a statistically statistically significant increase in the incidence of lung cancer in exposed workers and observation of tumors, generally astrocytomas in the brain, in studies in two rat strains exposed by various routes (drinking water, gavage, and inhalation) forms the basis for this classification.

A3; Confirmed animal carcinogen with unknown relevance to humans.

Evaluation: There is inadequate evidence in humans for the carcinogenicity of acrylonitrile. There is sufficient evidence in experimental animals for the carcinogenicity of acrylonitrile. Overall evaluation: Acrylonitrile is possibly carcinogenic to humans (Group 2B).

Acrylonitrile: reasonably anticipated to be a human carcinogen.

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