Propargyl Alcohol

CAS RN:107-19-7

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) USES: Higher alcohols are alcohols that contain more than 2 carbons, including 1-pentanol (amyl alcohol), used as an industrial solvent and synthetic flavoring agent. N-butanol and 2-methyl-2-butanol (amylene hydrate) have been used as human sedatives. Other higher alcohols are major ingredients in lacquer thinners, paint strippers, and solvents. Other industrial uses for higher alcohols include the manufacture of lacquers, chemicals, plastics, rubber, fruit essences, explosives, hydraulic fluid, pharmaceuticals, ceramics, textiles, disinfectants, and cleaning products.
    • B) TOXICOLOGY: Butanols and amyl alcohols (pentanols) are irritants to the eyes, mucous membranes, lungs and GI. Severity of gastric irritation correlates with lipid solubility. Higher alcohols are of a low order of toxicity in an industrial setting. As the carbon chain lengthens, the toxicity decreases. They are not able to penetrate skin as readily as smaller molecular weight alcohols and are less likely to be absorbed by inhalation. The exact mechanism is unknown.
    • C) EPIDEMIOLOGY: Products containing higher alcohols are widely available but not many exposures are reported to poison centers with patients presenting with severe effects being very rare.
    • D) WITH POISONING/EXPOSURE
      • 1) MILD TO MODERATE TOXICITY: Can cause gastrointestinal symptoms such as nausea, vomiting, abdominal cramps and diarrhea. Irritation of mucous membranes may also occur. Dermatitis of varying severity can happen with chronic exposure. Neurologic symptoms include headache, dizziness, giddiness, ataxia and sedation. Vapors from higher alcohols are irritating to the conjunctiva leading to burning, lacrimation, photophobia, corneal disturbances, and vision blurring.
      • 2) SEVERE TOXICITY: Can cause hypotension and cardiac dysrhythmias, and if aspirated, a hemorrhagic pneumonitis. With severe respiratory exposures, pulmonary edema can occur. Severe ingestions can cause gastrointestinal hemorrhage and liver injury. Finally, hypoglycemia can occur after exposure. After exposure to n-butanol vapor in combination with other solvents, there have been reports of formation of vacuoles in the cornea.
0.2.20 REPRODUCTIVE HAZARDS
  • A) Increased incidence of stillbirth and reduced weight gain in newborns were observed in experimental laboratory female mice given tert-butyl alcohol. Only slight teratogenicity in an inhalation teratology study of 3 butanol isomers.
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed