Vinyl methyl ether

CAS RN:107-25-5

Toxicity Summary

IDENTIFICATION AND USE: Vinyl methyl ether is a colorless compressed gas or colorless liquid. Copolymers are used in coatings and lacquers, as a modifier for alkyl, polystyrene and ionomer resins, and as a plasticizer for nitrocellulose and adhesives. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: Vinyl methyl ether does not produce inflammatory changes in either the skin or eyes of rabbits. Rats tolerate repeated inhalation of 2000 ppm. In two 28-day inhalation studies in rats restlessness, reduction in body weight gain and an increase in relative weight of the liver were observed at 25,000 ppm. In the male rats, an increase in prothrombin time and a reduction in total protein occured at higher concentrations. In the 28-day inhalation study, 1500 ppm was the no effect level for male rats and 3500 ppm for female rats. Methyl vinyl ether was not mutagenic on Salmonella typhimurium TA98, TA100, TA1535 and TA1537, and Escherichia` coli WP2 uvrA with or without metabolic activation. In the micronucleus test in mice, vinyl methyl ether did not produce a clastogenic effect following 5 exposures of 25,000 ppm.
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