Triethylamine

CAS RN:121-44-8

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) The primary clinical effects are irritation of the eyes, skin, and lungs, as well as central nervous system stimulation.
    • B) Ingestions have not been reported, but irritation or burns of the esophagus or gastrointestinal tract may be predicted to occur based on this agent's alkalinity and other irritant properties.
    • C) Myocardial degeneration was reported in rabbits exposed to 100 ppm for 6 weeks. This effect has not been reported in humans. This agent produces marked irritation of the lungs. Rabbits exposed to concentrations as low as 100 ppm developed pulmonary injury within 6 weeks. By extrapolation of animal data, pulmonary edema might be expected in severe exposures.
    • D) Triethylamine's central nervous system stimulant properties appear to be closely related to its inhibitory action on monoamine oxidase activity. Faintness and anxiety have been transient symptoms reported with agents in this class. Headache may be seen with systemic absorption.
    • E) Nausea has been a transient symptom reported by workers. Cellular necrosis of the liver was noted in rabbits exposed to 100 ppm for 6 weeks. This effect has not been reported in humans.
    • F) Triethylamine is irritating to the eyes and may cause corneal damage. A drop in rabbit eyes caused severe injury graded 9 on a scale of 1 to 10 after 24 hours. Chronic exposure to concentrations as low as 50 ppm has caused multiple erosions of the cornea and conjunctiva in rabbit eyes. Eye irritation and corneal edema have been reported in humans from industrial exposure.
    • G) This agent may cause dermatitis and skin burns. It may also be a sensitizing agent.
    • H) Experimental reproductive effects and experimental mutation data have been reported.
0.2.4 HEENT
  • 0.2.4.1 ACUTE EXPOSURE
    • A) This material is irritating to the eyes and may cause corneal damage due to its strong alkalinity. Eye irritation and corneal edema have been reported in humans from industrial exposures. Headache may also occur.
0.2.6 RESPIRATORY
  • 0.2.6.1 ACUTE EXPOSURE
    • A) This agent produces marked irritation of the lungs. Pulmonary edema is a possibility.
0.2.7 NEUROLOGIC
  • 0.2.7.1 ACUTE EXPOSURE
    • A) This compound's stimulant properties appear closely related to its MAO inhibitor activity.
0.2.14 DERMATOLOGIC
  • 0.2.14.1 ACUTE EXPOSURE
    • A) This agent may cause dermatitis and skin burns, aqueous solutions have a pH of approximately 10.
0.2.21 CARCINOGENICITY
  • 0.2.21.1 IARC CATEGORY
    • A) IARC Carcinogenicity Ratings for CAS121-44-8 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
      • 1) Not Listed
The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. The use of the Truven Health Analytics Inc. products is at your sole risk. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products.
Find more information on this substance at: Hazardous Substances Data Bank , TOXMAP , TOXNET , PubMed