Trimethyl Phosphite

CAS RN:121-45-9

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) USES: Irritants are a broad category of substances that cause inflammation and swelling but not cellular death or tissue damage, while corrosives cause cellular damage and death. Whether a substance is labeled a "corrosive" or "irritant" typically depends on several factors including concentration, viscosity, pH, molarity, oxidation-reduction potential, complexing affinity toward bivalent ions, etc. It can be difficult to determine whether a substance is a corrosive or irritant and the distinction may be concentration-dependent.
    • B) TOXICOLOGY: Irritants cause inflammation and swelling with local tissue irritation; this can lead to rhinorrhea, cough, shortness of breath, bronchospasm, irritation of oral mucous membranes and esophagus, and rarely upper airway swelling or acute lung injury.
    • C) WITH POISONING/EXPOSURE
      • 1) MILD TO MODERATE TOXICITY: Irritants may cause swelling, redness, and pain at any site, especially at mucous membranes. The mouth, nose, and eyes are commonly affected. After inhalation, cough, tachypnea, and wheezing are common. With ingestion, nausea, vomiting, and diarrhea are common. With dermal exposure, redness, swelling, and pain may occur.
0.2.20 REPRODUCTIVE HAZARDS
  • A) Pregnant female rats were exposed to N- methylpyrrolidone. Exposed offspring had normal motor function, activity levels, and low-level learning abilities. On higher-level learning tests, their performance was impaired compared to unexposed offspring.
0.2.21 CARCINOGENICITY
  • 0.2.21.2 HUMAN OVERVIEW
    • A) Development of sinonasal neoplasms has been associated with exposure to wood dust and other irritants.
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed