Cyanogen

CAS RN:460-19-5

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) SOURCES: Cyanide is primarily found as either a solid cyanide salt, a salt solution, or as hydrogen cyanide gas. It may be liberated as cyanide gas in house fires from the combustion of wool, silk, synthetic rubber, and polyurethane. It was previously found in artificial nail removers as acetonitrile.
    • B) USES: Various industries including metal extraction and refining, electroplating, photography, manufacturing, and fumigation.
    • C) PHARMACOLOGY: It is rapidly absorbed and has a very rapid onset of action.
    • D) TOXICOLOGY: Cyanide is a general cellular poison resulting in impaired oxygen utilization and lactic acidosis. It interferes with oxidative phosphorylation by inhibiting cytochrome oxidase which prevents aerobic production of energy.
    • E) EPIDEMIOLOGY: Rare exposure that can result in significant morbidity and mortality.
    • F) WITH POISONING/EXPOSURE
      • 1) MILD TO MODERATE TOXICITY: Nausea, vomiting, headache, weakness, confusion, dizziness and shortness of breath.
      • 2) SEVERE TOXICITY: Coma, transient loss of consciousness with apnea ("knockdown"), hypotension, metabolic acidosis, seizures, and dysrhythmias.
0.2.20 REPRODUCTIVE HAZARDS
  • A) There are no reported cases of human teratogenicity due to cyanide itself; however, teratogenic effects have been observed in experimental animals exposed to cyanide and related compounds.
0.2.21 CARCINOGENICITY
  • 0.2.21.1 IARC CATEGORY
    • A) IARC Carcinogenicity Ratings for CAS57-12-5 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
      • 1) Not Listed
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed