2,4-Toluene Diisocyanate

CAS RN:584-84-9

Protective Equip. / Clothing

Wear special protective clothing and positive pressure self-contained breathing apparatus. Butyl rubber, nitrile rubber, polyvinyl alcohol, polyvinyl chloride, or Viton barrier recommended.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Respirator Recommendations: At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentrations:
Assigned Protection Factor (APF) Respirator Recommendations
APF = 10,000 Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.
APF = 10,000 Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.
Respirator Recommendations: Escape:
Assigned Protection Factor (APF) Respirator Recommendations
APF = 50 Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.
Whenever there is potential for exposure to diisocyanates, even concentrations below the NIOSH REL, NIOSH recommends that employees be supplied with supplied-air respiratory protection. (Negative pressure air-purifying respirators are not recommended since diisocyanates have poor odor warning properties.) Also, there should be a respiratory protection program. /Diisocyanates/
NIOSH investigators recommend that dermal exposures to isocyanate-containing substances be prevented. Employers should provide protective clothing, gloves, and footwear that is impervious to isocyanate--containing compounds. The protective clothing should either be disposed or laundered after each use (e.g., at the end of the work shift). The gloves should be elbow-length and made of an isocyanate-resistant material. /Isocyanate-containing substances/
Face-shields and aprons should be used whenever there is a possibility of a splash or a spill of liquids containing isocyanate-containing materials. /Isocyanate-containing substances/
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed