2,4-Toluene Diisocyanate

CAS RN:584-84-9

Treatment Overview

0.4.2 ORAL EXPOSURE
  • A) Due to the irritant nature of this substance, emesis is not advised.
  • B) GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.
    • 1) CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion.
  • C) ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
  • D) Monitor patient for respiratory distress. If a cough or difficulty in breathing develops, evaluate for respiratory tract irritation, bronchitis and pneumonia.
  • E) Allergic reaction - Sensitized individuals should be cautioned to avoid further exposure as serious allergic reactions may result.
  • F) NOTE: See treatment of oral exposure in the main body of this document for complete information.
0.4.3 INHALATION EXPOSURE
  • A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.
  • B) The specific role of bronchodilators for treatment of severe bronchoconstriction has not been evaluated. Asthma from TDI can be induced in the absence of airway hyperresponsiveness; in these cases bronchodilator use may contribute little to modifying severity.
  • C) NOTE: See treatment of inhalation exposure in the main body of this document for complete information.
0.4.4 EYE EXPOSURE
  • A) DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.
  • B) NOTE: See treatment of eye exposure in the main body of this document for complete information.
0.4.5 DERMAL EXPOSURE
  • A) OVERVIEW
    • 1) DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
    • 2) NOTE: See treatment of dermal exposure in the main body of this document for complete information.
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed