Asbestos

CAS RN:1332-21-4

Carcinogenicity Evidence

There is sufficient evidence in humans for the carcinogenicity of all forms of asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite). Asbestos causes mesothelioma and cancer of the lung, larynx, and ovary. ... There is sufficient evidence in experimental animals for the carcinogenicity of all forms of asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite and anthophyllite). All forms of asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite and anthophyllite) are carcinogenic to humans (Group 1).
CLASSIFICATION: A; human carcinogen.
BASIS FOR CLASSIFICATION: Observation of increased mortality and incidence of lung cancer, mesotheliomas and gastrointestinal cancer in occupationally exposed workers are consistent across investigators and study populations. Animal studies by inhalation in two strains of rats showed similar findings for lung cancer and mesotheliomas. Animal evidence for carcinogenicity via ingestion is limited (male rats fed intermediate-range chrysotile fibers; i.e., greater than (>) 10 um length, developed benign polyps), and epidemiologic data in this regard are inadequate.
HUMAN CARCINOGENICITY DATA: Sufficient.
ANIMAL CARCINOGENICITY DATA: Sufficient.
A1: Confirmed human carcinogen. /Asbestos, all forms/
Asbestos and all commercial forms of asbestos are known to be human carcinogens based on sufficient evidence of carcinogenicity from studies in humans. /Asbestos/
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