Stibine

CAS RN:7803-52-3

Toxicity Summary

IDENTIFICATION AND USE: Stibine is a colorless gas. High purity stibine is used as an n-type gas phase dopant for silicon in semiconductors. It has been used as fumigating agent. It is also used in the production of lead batteries. HUMAN STUDIES: Stibine is a toxic gas that has effects similar to those of arsine, but stibine is not encountered as frequently as arsine. The most likely route of exposure to stibine is inhalation. Stibine attacks the blood and central nervous system. In acute poisoning, the signs in man are headache, nausea, weakness, slow breathing, and weak and irregular pulse. One of the early signs of overexposure to stibine in man may be hemoglobinuria. Laboratory findings may include: anemia, elevated bilirubin (indirect), hyperkalemia, damaged red blood cells (basophilic stippling, anisocytosis, Heinz-Ehrlich bodies), low haptoglobin, elevated plasma-free hemoglobin levels, elevated urinary hemoglobin, elevated blood urea nitrogen (BUN) and creatinine, abnormal liver function tests, thrombocytopenia. Stibine gas is not capable of inhibiting cholinesterase activity at toxicologically relevant concentrations. ANIMAL STUDIES: The odorless toxic gas stibine, like arsine, is a potent hemolytic agent. The lethal concentration of stibine in air for mice is about 100 ppm for 1.6 hr. The formation of Heinz bodies in red blood cells was associated with acute stibine exposure that may underlie its hemolytic effects. Stibine was found genotoxic in vitro (significant nicking to pBR 322 plasmid DNA).
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