Nickel Carbonyl

CAS RN:13463-39-3

Laboratory

A) Monitor serum electrolytes, renal function and CBC. Institute continuous cardiac monitoring and obtain an ECG.
B) Monitor urinary nickel concentrations after suspected exposure and during chelation. Blood nickel carbonyl concentrations are not clinically useful since nickel carbonyl is rapidly metabolized and eliminated. Nickel carbonyl is not typically measurable in the blood of exposed individuals. Urinary nickel concentrations are the best indicator of the severity of poisoning, and urinary nickel concentrations correlate well with clinical symptoms in acute exposures.
C) Some authors suggest monitoring carboxyhemoglobin concentrations as carbon monoxide is a result of nickel carbonyl decomposition. Monitor symptomatic patients as indicated. Inhalation of inhaled nickel carbonyl rapidly decomposes to nickel and carbon monoxide.
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed