Dimethyl Sulfoxide

CAS RN:67-68-5

Major Uses

DMSO is not a nutritional supplement. It is used as a treatment for interstitial cystitis, and treatment must be performed by a qualified physician. DMSO is metabolized to methylsulfonylmethane, which is available as a nutritional supplement.
Vitrification has become common for cryopreservation of embryos. ...Extended exposure of embryos with both vitrification protocols showed that the DMSO-containing vitrification solutions did not lead to cell membrane damage and death as quickly as the DMSO-free vitrification solutions. To assess embryo viability, the authors recommend that vitrification of early embryos should be combined with extended culture and assessment of normal blastocyst development before transferring to patients.
Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). ... The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery.
For dimethyl sulfoxide (USEPA/OPP Pesticide Code: 000177) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
Reagent in organic synthesis. Industrial solvent; as antifreeze or hydraulic fluid when mixed with water. To cryopreserve and store cultured cells.
Solvent for polymerization and cyanide reactions; analytical reagent; spinning polyacrylonitrile and other synthetic fibers; industrial cleaners, pesticides; paint stripping, hydraulic fluids; preservation of cells at low temperatures; diffusion of drugs, etc., into blood stream by topical application; medicine (antiinflammatory; veterinary medicine; plant pathology and nutrition; pharmaceutical products; metal-complexing agent.
Dimethyl sulfoxide is used as a solvent for the polymerization of acrylonitrile and other vinyl monomers. Copolymerization reactions of acrylonitrile with other vinyl monomers are also run in dimethyl sulfoxide. Dimethyl sulfoxide can also be used as a reaction solvent for other polymerizations. Dimethyl sulfoxide is used as the reaction solvent in the manufacture of high performance, polyaryl ether polymers by reaction of bis(4,4-chlorophenyl) sulfone with the disodium salts of dihydroxyphenols, eg, bisphenol A or 4,4-sulfonylbisphenol. Its is used as an extraction solvent, solvent for electrolytic reactions, pesticide solvent, and to remove urethane polymers and other difficult-to-solvate materials from processing equipment.
Registration Notes: USA - An exemption has been established by the EPA from the requirements of tolerance for dimethyl sulfoxide when used as an inert solvent with diazinon or carbaryl in or on raw agricultural commodities, peas without pods, pea vines or dried vines as hay and whole pea crop as forage.
Reported uses (ppm):
Reported uses (ppm): (Flavor and Extract Manufacturers' Association)

Food Category Usual Max.
Baked goods 0.10 5.00
Breakfast cereals 0.10 5.00
Frozen dairy 0.10 5.00
Gravies 0.10 5.00
Meat products 0.10 5.00
Milk products 0.10 5.00
Nonalcoholic beverages 0.10 5.00
Seasonings, flavors 100.00 1,000.00
Soft candy 0.10 5.00
Soups 0.10 5.00
Sweet sauce 0.10 5.00
Dimethyl sulfoxide is a prescription medicine and dietary supplement. Effective for interstitial cystitis when used as an FDA-approved product. Possibly Effective for decreasing pain caused by the herpes zoster virus (shingles) when used with a drug called idoxuridine, inflammatory bladder disease, and treating skin and tissue damage caused by chemotherapy when it leaks from the IV.
Medication (vet):
Dimethyl sulfoxide is an excellent solvent that is widely used for reactions in modern chemistry. ... In plant protection, DMSO can be used to ward off mammals (e.g., deer) and as a growth stimulant.
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed