Dimethyl Sulfoxide

CAS RN:67-68-5

Treatment Overview

  • A) Emesis should NOT be induced, since this is a solvent and aspiration is possible. If large amounts have been ingested, consider lavage after intubation.
  • B) ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
  • C) SUPPORTIVE CARE - Monitor the patient's liver function, kidney function, hemoglobin, and platelet function.
  • D) PERITONEAL DIALYSIS was tried in one case report (Yellowlees et al, 198
    • 0) and deemed not effective.
  • A) DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.
    • 1) DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999).
    • 2) Rashes are common reactions that may need physical examination.
    • 3) DMSO carries other substances through the skin. Take a careful history as to what other chemicals might be involved, and observe for toxic effect from these chemicals.
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed