Dibromomethane

CAS RN:74-95-3

Range of Toxicity

A) TOXICITY: ZINC OXIDE: Legal workplace limit (OSHA): 5 mg/m(3) averaged over an 8-hour work shift. Permissible exposure limit (NIOSH): 5 mg/m(3) averaged over a work shift up to 10 hours per day, 40 hours per week with a short-term exposure limit of 10 mg/m(3) averaged over a 15 minute period. A time weighted average (ACGIH): 2 mg/m(3) for an 8-hour work day and 40-hour work week. Symptoms have been reported with levels below 5 mg/m(3) but levels of 14 mg/m(3) have been well-tolerated for 8-hour exposures. A level of 45 mg/m(3) was tolerated for 20 minutes but levels above this are generally poorly tolerated.
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A) TOXICITY: Inhalation is the usual route of occupational exposure. OSHA's short-term exposure limit: 125 ppm; 8-hour permissible exposure limit: 25 ppm; NIOSH immediately dangerous to life and health concentration: 2300 ppm. For humans, 50,000 ppm is considered life-threatening. The lowest oral dose reported to cause death is 357 mg/kg.
B) Patients usually develop toxicity after ingestions of more than 25 mL of dichloromethane.
C) Methylene chloride is metabolized to carbon monoxide, resulting in carboxyhemoglobin in the blood and toxic effects. When heated to decomposition, methylene chloride releases toxic phosgene, hydrogen chloride gas, and chlorine gas.
The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. The use of the Truven Health Analytics Inc. products is at your sole risk. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products.
A) TOXICITY: There is great interpatient variability in symptoms at a given serum bromide concentration. Most toxicity develops after chronic ingestion. Serum bromide concentrations of 50 to 100 mg/dL may be associated with symptoms; 200 mg/dL will produce toxic symptoms; 300 mg/dL may be fatal. Acute ingestion of 4500 mg bromovalerylurea caused lethargy and myoclonus in an adult. Chronic consumption of 0.5 to 1 g bromides/day may cause bromism.
B) THERAPEUTIC DOSE: Adults: Acceptable daily intake: 1 mg/kg.
The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. The use of the Truven Health Analytics Inc. products is at your sole risk. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products.
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