CAS RN:55-63-0

Range of Toxicity

A) TOXICITY: Toxicity has not been established in adults or children. ADULT: Some patients develop hypotension after a therapeutic sublingual dose. Ingestion of 25 sublingual tablets is unlikely to cause toxicity because of extensive first pass metabolism. Severity of intoxication should be based on clinical findings.
B) THERAPEUTIC: ADULT: Varies according to indication. ACUTE ANGINA: 0.3 to 0.6 mg sublingually every 5 min for a maximum of 3 doses in 15 min. HYPERTENSION: 5 mcg/min can be given IV increasing 5 mcg/min every 3 to 5 minutes for a max dose of 200 mcg/min IV. PEDIATRIC: Hypertension or congestive heart failure: 1 to 5 mcg/kg/min.
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