Ethylene Oxide

CAS RN:75-21-8

Carcinogenicity Evidence

A2; Suspected human carcinogen.
Evaluation: There is limited evidence in humans for the carcinogenicity of ethylene oxide. There is sufficient evidence in experimental animals for the carcinogenicity of ethylene oxide. In making the overall evaluation, the Working Group took into consideration the following supporting evidence. Ethylene oxide is a directly acting alkylating agent that: (1) induces a sensitive, persistent dose-related increase in the frequency of chromosomal aberrations and sister chromatid exchange in peripheral lymphocytes and micronuclei in bone marrow cells of exposed workers; (2) has been associated with malignancies of the lymphatic and hematopoietic system in both humans and experimental animals; (3) induces a dose related increase in the frequency of hemoglobin adducts in exposed humans and dose related increases in the numbers of adducts in DNA and hemoglobin in exposed rodents; (4) induces gene mutations and heritable translocations in germ cells of exposed rodents; and (5) is a powerful mutagen and clastogen at all phylogenetic levels. Overall evaluation: Ethylene oxide is carcinogenic to humans (Group 1).
Ethylene Oxide: known to be a human carcinogen.
Find more information on this substance at: Hazardous Substances Data Bank , TOXNET , PubMed