1,1-Dichloroethane

CAS RN:75-34-3

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) At the time of this review, no studies of acute oral toxic effects in humans were found. Overall toxicity is thought to be less than its isomer 1,2-dichloroethane. Animal studies indicated that 1,1-dichloroethane is well absorbed by ingestion. The central nervous system (CNS), cardiovascular, hepatic and renal systems may be adversely affected. Death may be due to cardiac dysrhythmias, or aspiration. Neurologic effects have been reported including headache, weakness, vertigo, tremor, and dizziness.
    • B) INHALATION - Vapors may produce irritation of the respiratory tract and conjunctiva, CNS depression, and cardiac dysrhythmias.
    • C) DERMAL - 1,1-dichloroethane is a skin, mucous membrane and eye irritant. The liquid is readily absorbed through the skin, thus systemic effects may occur.
    • D) EYE - Contact with either the liquid or with high concentrations of vapor causes immediate discomfort. Conjunctival and corneal injury may occur.
    • E) When heated to decomposition, toxic fumes of carbon monoxide, carbon dioxide, hydrogen chloride gas, and phosgene are emitted.
0.2.4 HEENT
  • 0.2.4.1 ACUTE EXPOSURE
    • A) Vapor exposure may result in respiratory tract irritation and a burning sensation.
0.2.5 CARDIOVASCULAR
  • 0.2.5.1 ACUTE EXPOSURE
    • A) Acute inhalation of high concentrations may result in cardiac dysrhythmias such as ventricular fibrillation.
0.2.6 RESPIRATORY
  • 0.2.6.1 ACUTE EXPOSURE
    • A) Coughing progressing to acute lung injury, tachypnea, and cyanosis may occur.
0.2.7 NEUROLOGIC
  • 0.2.7.1 ACUTE EXPOSURE
    • A) 1,1-dichloroethane is s a CNS depressant. Dizziness, headache, mental confusion, lethargy, coma or seizures may occur. In severe exposures, CNS depression leading to respiratory arrest may occur.
0.2.8 GASTROINTESTINAL
  • 0.2.8.1 ACUTE EXPOSURE
    • A) Nausea, vomiting, anorexia, and abdominal pain may be noted.
0.2.9 HEPATIC
  • 0.2.9.1 ACUTE EXPOSURE
    • A) Liver toxicity may be noted as a late finding.
0.2.10 GENITOURINARY
  • 0.2.10.1 ACUTE EXPOSURE
    • A) Oliguria, anuria, and renal failure may be noted as a late finding. Complete recovery is usual.
0.2.14 DERMATOLOGIC
  • 0.2.14.1 ACUTE EXPOSURE
    • A) Dermal exposure may result in skin burns or red scaly rash.
0.2.20 REPRODUCTIVE HAZARDS
  • A) At the time of this review, no studies were found on the potential human reproductive effects of 1,1-dichloroethane.
  • B) Skeletal abnormalities were noted in the offspring of pregnant rats exposed to 6000 ppm of days 6-15 of gestation.
0.2.21 CARCINOGENICITY
  • 0.2.21.1 IARC CATEGORY
    • A) IARC Carcinogenicity Ratings for CAS75-34-3 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
      • 1) Not Listed
  • 0.2.21.2 HUMAN OVERVIEW
    • A) At the time of this review, no reports of carcinogenicity in humans were found.
    • B) The ACGIH states that 1,1-dichloroethane is not classifiable as a human carcinogen (ACGIH, 1996a).
  • 0.2.21.3 ANIMAL OVERVIEW
    • A) In animal dosing studies, the incidence of endometrial stromal polyps was statistically increased. There appeared to be a dose-related trend in the incidence of hemangiosarcomas, mammary sarcomas, and hepatocellular carcinomas.
0.2.22 GENOTOXICITY
  • A) At the time of this review, no human genotoxicity data following exposure to 1,1-dichloroethane was available. 1,1-dichloroethane may bind to proteins, RNA, and DNA in experimental animals.
The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. The use of the Truven Health Analytics Inc. products is at your sole risk. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products.
Find more information on this substance at: Hazardous Substances Data Bank , TOXMAP , TOXNET , PubMed