Phencyclidine

CAS RN: 77-10-1

Key Info

CLINICAL EFFECTS

0.2.1 SUMMARY OF EXPOSURE
A) USES: Phencyclidine (PCP, 1-(1-phenylcyclohexyl)-piperidine) is a dissociative anesthetic, and is abused for its hallucinogenic
properties. It is related to ketamine, which is widely used as a sedation medication, but ketamine is much less potent than phencyclidine.
B) TOXICOLOGY: Phencyclidine is thought to stimulate alpha-adrenergic receptors, potentiating the effects and/or inhibition of
reuptake of norepinephrine, epinephrine, and serotonin. It is also thought to stimulate opioid receptors and inhibit NMDA receptors.
In overdose, acute psychosis and sympathomimetic toxidrome can produce agitated delirium. In large overdoses, patients may progress
to coma.
C) EPIDEMIOLOGY: Exposure to phencyclidine is uncommon. Severe toxicity is rare. Deaths have been reported but are most often
due to trauma rather than to direct drug effects.
D) WITH POISONING/EXPOSURE
1) MILD TO MODERATE TOXICITY: Mild toxicity results in tachycardia, hypertension, hallucinations, euphoria, and disinhibition.
Phencyclidine can also cause mild agitation and acute changes in mood. Nystagmus is often prominent on physical exam.
2) SEVERE TOXICITY: Severe toxicity can cause psychosis, severe psychomotor agitation and hyperthermia. Rhabdomyolysis, multisystem
organ failure, and metabolic acidosis can result from the hyperstimulation. Seizures, followed by coma and death are ultimate
CNS outcomes in severe toxicity.

0.2.20 REPRODUCTIVE
A) PCP crosses the placenta and may result in neonatal irritability, jitteriness, coarse tremors, nystagmus, and poor feeding.

FIRE FIGHTING PROCEDURES

As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective
clothing.
Water spray, dry chemical, carbon dioxide or foam as appropriate for surrounding fire and materials.


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