Pseudoephedrine

CAS RN: 90-82-4

Key Info

CLINICAL EFFECTS

0.2.1 SUMMARY OF EXPOSURE
A) USES: Commonly used in cough and cold medications as a decongestant, both alone and in combination with other cough preparations.
However, it is also abused for its stimulant properties.
B) EPIDEMIOLOGY: Widely used as a decongestant in both pediatric and adult patients. Both intentional and unintentional ingestions
are commonly encountered. Severe toxicity is rare and there are no clear reports of death due to single substance ingestion.
C) PHARMACOLOGY: In general, it stimulates the adrenergic nervous system. Pseudoephedrine is a mixed acting nonspecific alpha
1 and 2, and beta 1 and 2 adrenergic receptor agonist.
D) TOXICITY: Adverse effects result from excessive stimulation of the adrenergic nervous system.
E) WITH THERAPEUTIC USE
1) ADVERSE EVENTS: CV: Tachyarrhythmia and hypertension are common. CNS: Anxiety, nervousness, insomnia, irritability and muscle
tremor (usually hands) commonly occurs. WITHDRAWAL may develop with chronic use.
F) WITH POISONING/EXPOSURE
1) MILD TO MODERATE TOXICITY: Symptoms commonly seen in the overdose setting include: vomiting, mydriasis, hypertension, tachycardia,
agitation and anxiety. Reflexive bradycardia from hypertension has also been reported. Dermal reactions are common.
2) SEVERE TOXICITY: Sinus dysrhthymias have occurred. Rarely seen symptoms include: intracranial hemorrhages, seizures, myocardial
infarction, ischemic bowel infarction and psychosis. Hypokalemia has developed in overdose. Drowsiness has developed in children
following overdose.

0.2.20 REPRODUCTIVE
A) Pseudoephedrine and the combinations of chlorpheniramine/pseudoephedrine, guaifenesin/hydrocodone/pseudoephedrine, and guaifenesin/pseudoephedrine
are classified as US FDA pregnancy category C. Pseudoephedrine is excreted in human breast milk in low amounts.

Find more information on this substance at: PubChem, PubMed