Formamide

CAS RN: 75-12-7

Key Info

CLINICAL EFFECTS

0.2.1 SUMMARY OF EXPOSURE

0.2.1.1 ACUTE EXPOSURE
A) A SPECIFIC REVIEW on the clinical effects and treatment of individuals exposed to this agent HAS NOT YET BEEN PREPARED. The
following pertains to the GENERAL EVALUATION and TREATMENT of individuals exposed to potentially toxic chemicals.
B) GENERAL EVALUATION -
1) Exposed individuals should have a careful, thorough medical history and physical examination performed, looking for any abnormalities.
Exposure to chemicals with a strong odor often results in such nonspecific symptoms as headache, dizziness, weakness, and nausea.
C) IRRITATION -
1) Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can
progress to ARDS/acute lung injury, which may be delayed in onset for up to 24 to 72 hours in some cases.
2) Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested.
D) HYPERSENSITIVITY -
1) A number of chemical agents produce an allergic hypersensitivity dermatitis or asthma with bronchospasm and wheezing with
chronic exposure.

REACTIVITIES & INCOMPATIBILITIES

Incompatible with iodine, pyridine and sulfur trioxide.
Bottles containing a modified Karl Fischer reagent with formamide replacing methanol developed gas pressure during several months
and burst. No reason was apparent, but slow absorption of moisture, formation of sulfuric acid and liberation of carbon monoxide
from the formamide seems a likely sequence.
A mixture containing 51% of calcium nitrate and 12% ammonium nitrate with 27% formamide and 10% water is detonable @ -20 deg C.

Oxidizers, iodine pyridine, sulfur, trioxide, copper, brass, lead [Note: Hygroscopic (i.e., absorbs moisture from the air)].
Formamide is hydrolyzed very slowly at room temperature. Acids, bases and elevated temperatures accelerate the hydrolysis.

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