2-Xylene

CAS RN: 95-47-6

Range of Toxicity

A) TOXICITY: There is little information concerning the toxic oral dose of xylene in humans. ORAL: The estimated oral lethal dose is 15 to 30 mL. INHALATION: Inhalational exposure to 1000 ppm is considered immediately dangerous to life or health. Two deaths have resulted from 12+ hours of xylene exposure, estimated to be greater than 6000 ppm. There are case reports of adults dying at exposures of 10,000 ppm after 6 hours and up to 18.5 hours of exposure. At 200 ppm, there have been reports of conjunctivitis and respiratory effects and patients have been symptomatic after exposure of 100 ppm for 8 hours. PARENTERAL: An intravenous injection of 8 mL (0.1 mL/kg) of xylene resulted in life-threatening respiratory failure in a patient who survived with aggressive supportive care.
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