CAS RN: 95-47-6

Carcinogenicity Evidence

Evaluation: There is inadequate evidence in humans for the carcinogenicity of xylenes. There is inadequate evidence in experimental animals for the carcinogenicity of xylenes. Overall classification: Xylenes are not classifiable as to their carcinogenicity to humans (Group 3)./Xylenes, o,m,p isomers/
CLASSIFICATION: D; not classifiable as to human carcinogenicity.
BASIS FOR CLASSIFICATION: Orally administered technical xylene mixtures did not result in significant increases in incidences in tumor responses in rats or mice of both sexes.
ANIMAL CARCINOGENICITY DATA: Inadequate. /based on former classification system/
Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), data are inadequate for an assessment of the carcinogenic potential of xylenes. Adequate human data on the carcinogenicity of xylenes are not available, and the available animal data are inconclusive as to the ability of xylenes to cause a carcinogenic response. Evaluations of the genotoxic effects of xylenes have consistently given negative results. /Xylenes/
A4; Not classifiable as a human carcinogen. /Xylene (o-, m-, & p-isomers)/
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