3-Bromo-1-propyne

CAS RN: 106-96-7

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) Little is known about the potential systemic toxicity of this agent. Propargyl bromide is a strong lacrimator and skin irritant. Direct contact can cause corrosion of the eyes, skin, and mucous membranes. Liver and kidney injury have been seen in exposed experimental animals.
0.2.4 HEENT
  • 0.2.4.1 ACUTE EXPOSURE
    • A) Eye, nose, and throat irritation may be seen.
0.2.6 RESPIRATORY
  • 0.2.6.1 ACUTE EXPOSURE
    • A) Respiratory tract irritation with potential chemical pneumonitis or noncardiogenic pulmonary edema may occur.
0.2.8 GASTROINTESTINAL
  • 0.2.8.1 ACUTE EXPOSURE
    • A) Esophageal or GI tract irritation or burns may occur.
0.2.9 HEPATIC
  • 0.2.9.1 ACUTE EXPOSURE
    • A) Hepatic injury has occurred in experimental animals.
0.2.10 GENITOURINARY
  • 0.2.10.1 ACUTE EXPOSURE
    • A) Kidney injury has occurred in experimental animals.
0.2.14 DERMATOLOGIC
  • 0.2.14.1 ACUTE EXPOSURE
    • A) Dermal irritation or burns may be seen.
0.2.20 REPRODUCTIVE HAZARDS
  • A) At the time of this review, no data were available to assess the potential reproductive hazard of propargyl bromide.
0.2.21 CARCINOGENICITY
  • 0.2.21.1 IARC CATEGORY
    • A) IARC Carcinogenicity Ratings for CAS106-96-7 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
      • 1) Not Listed
  • 0.2.21.2 HUMAN OVERVIEW
    • A) At the time of this review, no data were available to assess the possible carcinogenic and mutagenic potential of this agent.
0.2.22 GENOTOXICITY
  • A) No genetic studies were found for propargyl bromide. It is predicted to be genotoxic because it is an alkylating agent.
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