A) Chlorobenzene is a skin and mucous membrane irritant. Exposures may result in central nervous system depression and liver and kidney damage. Intentional ingestions have resulted in hepatic necrosis. Acute exposures may begin, depending on dose, with headaches and dizziness followed by gastrointestinal complaints, shortness of breath, tachycardia and circulatory insufficiency.
B) Chronic inhalation exposures may result in eye irritation, headache, dizziness, somnolence and gastrointestinal disorders. Acute inhalation exposures to high concentrations may result in narcosis. There is no evidence that severe liver damage results from acute inhalation exposures.
0.2.6 RESPIRATORY
0.2.6.1 ACUTE EXPOSURE
A) Shortness of breath may develop following acute exposures.
B) In animal lethality studies, death was attributed to CNS depression resulting in respiratory failure.
0.2.7 NEUROLOGIC
0.2.7.1 ACUTE EXPOSURE
A) Chlorobenzene is a CNS depressant following high dose acute inhalation and oral exposures. In animal lethality studies, death was attributed to CNS depression resulting in respiratory failure.
0.2.8 GASTROINTESTINAL
0.2.8.1 ACUTE EXPOSURE
A) Ingestion may result in gastric irritation.
0.2.9 HEPATIC
0.2.9.1 ACUTE EXPOSURE
A) Acute ingestions have resulted in hepatic necrosis.
0.2.10 GENITOURINARY
0.2.10.1 ACUTE EXPOSURE
A) Chlorobenzene is nephrotoxic in animal studies.
0.2.20 REPRODUCTIVE HAZARDS
A) In rat and rabbit inhalational studies, chlorobenzene was considered to lack embryonic and fetal toxicity.
0.2.21 CARCINOGENICITY
0.2.21.1 IARC CATEGORY
A) IARC Carcinogenicity Ratings for CAS108-90-7 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
1) Not Listed
0.2.21.2 HUMAN OVERVIEW
A) Existing data are inadequate to define the potential for chlorobenzene exposures to cause cancer in humans and animals.
0.2.22 GENOTOXICITY
A) Existing data do not support genotoxicity in humans following exposures.
The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. The use of the Truven Health Analytics Inc. products is at your sole risk. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products.
