Ethanol

CAS RN: 64-17-5

Range of Toxicity

A) TOXICITY: Ethanol levels that cause clinical intoxication can vary widely, depending on an individual's tolerance to ethanol. The legal driving limit in most of the states in the US is 80 mg/dL. In casual drinkers, coma likely occurs at a level of approximately 200 mg/dL, and death may occur at an approximate level of 450 mg/dL.
B) A dose of about 1 mL/kg (1 g/kg) of absolute ethanol (95% to 99% ethanol) generally results in blood levels of 100 to 150 mg/dL (21 to 32 mmol/L), which would be expected to cause mild to moderate intoxication in most adults. However, a dose of 0.5 mL/kg absolute ethanol (an estimated blood alcohol level of 50 to 75 mg/dL) may cause significant intoxication in young children.
C) INTOXICATION: Blood ethanol concentrations between 150 and 300 mg/dL (32.6 to 65.2 mmol/L) will generally cause obvious signs and symptoms.
D) DEATH Generally reported at 5 to 6 g/kg in the non-tolerant adult and at 3 g/kg in children. Usually associated with blood ethanol levels greater than 400 mg/dL (86.8 mmol/L), although levels as low as 250 mg/dL have proven fatal. Cases of ethanol ingestion complicated by aspiration of gastric contents, coingestants, preexisting disease, or other factors may cause death at lower blood ethanol levels.
E) RECOVERY Reported in patients with blood ethanol levels greater than 1510 mg/dL (327.8 mmol/L). Supportive care was provided; a history of chronic ethanol abuse (and thus tolerance) was present in at least 1 case.
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