Propylene

CAS RN: 115-07-1

Toxicity Summary

IDENTIFICATION AND USE: Propylene is a colorless gas. It is used in manufacture of isopropyl alcohol, polypropylene, synthetic glycerol, acrylonitrile, propylene oxide, heptene, cumene, polymer gasoline, acrylic acid, vinyl resins, oxo chemicals. It is also used as aerosol propellant and component. Formerly used in dental surgery as temporary anesthetic. HUMAN STUDIES: In the gaseous state propylene is not irritating to the skin or eyes based on limited human studies. However, should skin or eye contact occur to this chemical in its liquid state, tissue freezing, severe cold burn, and/or frostbite may result. ANIMAL STUDIES: No adverse effects were observed in repeated dose inhalation toxicity studies in rodents at concentrations up to 10,000 ppm propylene, for 14 weeks. Furthermore, there was no evidence of carcinogenicity in rats or mice exposed to propylene concentrations as high as 10,000 ppm for up to 103 weeks. Inflammation of the nasal cavity was the only indication of toxicity observed following exposure of male rats to 5,000 and 10,000 ppm propylene and female rats exposed to 10,000 propylene for 103 weeks. These effects were not observed when rats were exposed to similar concentrations for 14 weeks. Mutagenic activity was observed in a single bacterial strain in the Ames assay in the presence of metabolic activation. Inhalation exposure of pregnant Wistar rats to propylene from implantation to one day prior to the expected day of parturition (days 6-19 p.c.) elicited no maternal toxicity, prenatal or developmental toxicity, or teratogenicity at all tested concentrations up to 10,000 ppm.
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