Methanol

CAS RN: 67-56-1

Laboratory

A) Monitor mental status, vital signs, and ECG.
B) In patients with significant CNS depression or metabolic acidosis, obtain arterial or venous blood gases.
C) Obtain a serum methanol and ethanol concentration and serial serum electrolytes; calculate anion gap.
D) If serum methanol cannot be obtained in a timely fashion, measure serum osmolality and calculate osmolal gap. The osmolal gap is equal to the measured serum osmolality minus (2 x serum sodium + BUN/2.8) + glucose/18 + ethanol/4.6). An elevated osmolal gap (greater than 10) suggests the presence of toxic alcohols, but a normal osmolal gap does NOT rule this out.
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