Isopropanol

CAS RN: 67-63-0

Exposure Summary

Isopropanol's production and use in the manufacture of acetone, glycerol, and isopropyl acetate and as a solvent for a variety of applications may result in its release to the environment through various waste streams. Isopropanol's use in hydraulic fracturing fluids results in its direct release to the environment. Isopropanol has been identified as a metabolic product of aerobic microorganisms, anaerobic microorganisms, fungi, and yeast. If released to air, a vapor pressure of 45.4 mm Hg at 25 deg C indicates isopropanol will exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropanol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3.2 days. If released to soil, isopropanol is expected to have very high mobility based upon an estimated Koc of 1.5. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 8.10X10-6 atm-cu m/mole. Isopropanol is expected to volatilize from dry soil surfaces based upon its vapor pressure. If released into water, isopropanol is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 86 hours and 29 days, respectively. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups. Biodegradation is expected to be an important fate process based on the results of microbial screening tests. Occupational exposure to isopropanol may occur through inhalation and dermal contact with this compound at workplaces where isopropanol is produced or used. Monitoring data indicate that the general population may be exposed to isopropanol via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with this compound directly and from consumer products containing isopropanol. (SRC)
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