Propionic Anhydride

CAS RN: 123-62-6

Other Preventive Measures

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Where hazardous chemicals as defined by the OSHA laboratory standard are used in the workplace, the employer shall develop and carry out the provisions of a written Chemical Hygiene Plan ... The Chemical Hygiene Plan /must/ include each of the following elements ...; Standard operating procedures relevant to safety and health considerations to be followed when laboratory work involves the use of hazardous chemicals; Criteria that the employer will use to determine and implement control measures to reduce employee exposure to hazardous chemicals including engineering controls, the use of personal protective equipment and hygiene practices; ... ; A requirement that fume hoods and other protective equipment are functioning properly and specific measures .../to/ be taken to ensure ... performance of such equipment; Provisions for employee information and training ... The circumstances under which a particular laboratory operation, procedure or activity shall require prior approval from the employer or the employer's designee before implementation; Provisions for medical consultation and medical examinations ... ; Designation of personnel responsible for implementation of the Chemical Hygiene Plan including the assignment of a Chemical Hygiene Officer, and, if appropriate, establishment of a Chemical Hygiene Committee; and Provisions for additional employee protection for work with particularly hazardous substances. These include "select carcinogens," reproductive toxins and substances which have a high degree of acute toxicity.
The following provisions /of the OSHA laboratory standard/ ... apply to chemical substances developed in the laboratory: If the composition of the chemical substance which is produced exclusively for the laboratory's use is known, the employer shall determine if it is a hazardous chemical ... . /and/ ... provide appropriate training ... . If the chemical produced is a byproduct whose composition is not known, the employer /must/ assume that the substance is hazardous ... . If the chemical substance is produced for another user outside of the laboratory, the employer /must/ comply with the Hazard Communication Standard (29 CFR 1910.1200) including the requirements for preparation of material safety data sheets and labeling.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.
/When working in contact with org acid anhydrides/ adequate ventilation should be provided ... . /Organic acid anhydrides/
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.
Exposure treatment: inhalation: move victim to fresh air; if breathing has stopped, give artificial respiration. Eyes: Immediately flush with plenty of water for at least 15 min; get medical attention. Skin: immediately flush with plenty of water for at least 15 min. Ingestion: give large amounts of water, do not induce vomiting.
Prevent generation of mists! Avoid all contact! /Use/ ventilation, local exhaust, or breathing protection. /Wear/ protective gloves; protective clothing; face shield, or eye protection in combination with breathing protection. Do not eat drink, or smoke during work. /from table/
If material not on fire and not involved in a fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. Neutralize spilled material with crushed limestone, soda ash, or lime.
Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. If contact with the material anticipated, wear appropriate chemical protective clothing.
Find more information on this substance at: PubChem, PubMed