CAS RN: 123-91-1

Carcinogenicity Evidence

Evaluation: There is inadequate evidence in humans for the carcinogenicity of 1,4-dioxane. There is sufficient evidence in experimental animals for the carcinogenicity of 1,4-dioxane. Overall evaluation: 1,4-Dioxane is possibly carcinogenic to humans (Group 2B).
1,4-dioxane is characterized as "likely to be carcinogenic to humans." This characterization is based on the following findings: (1) inadequate evidence of carcinogenicity in humans, and (2) sufficient evidence in animals (i.e., hepatic tumors in multiple species [three strains of rats, two strains of mouse, and in guinea pigs] mesotheliomas of the peritoneum, mammary, and nasal tumors have also been observed in rats following 2 years of oral exposure to 1,4- dioxane).
A3: Confirmed animal carcinogen with unknown relevance to humans.
1,4-Dioxane: reasonably anticipated to be a human carcinogen.
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