As of February 28th, 2023, NLM will discontinue the Wireless Information System for Emergency Responders (WISER), the website (https://wiser.nlm.nih.gov) and WebWISER (https://webwiser.nlm.nih.gov), and the standalone applications for Windows PCs, iOS app, and Android app.
Other sources of Hazmat or Chemical, Biological, Radiological, Nuclear (CBRN) information are available with the following resources:
This WISER content is available in multiple languages.
Protective Equipment / Clothing
Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Sigma-Aldrich; Material Safety Data Sheet for Acetone. Product Number: 270725, Version 4.10 (Revision Date 11/24/2014). Available from, as of January 5, 2015: <http://www.sigmaaldrich.com/safety-center.html/>.
Handle with gloves.
Sigma-Aldrich; Material Safety Data Sheet for Acetone. Product Number: 270725, Version 4.10 (Revision Date 11/24/2014). Available from, as of January 5, 2015: <http://www.sigmaaldrich.com/safety-center.html/>.
Body Protection: Impervious clothing, flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Sigma-Aldrich; Material Safety Data Sheet for Acetone. Product Number: 270725, Version 4.10 (Revision Date 11/24/2014). Available from, as of January 5, 2015: <http://www.sigmaaldrich.com/safety-center.html/>.
Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Sigma-Aldrich; Material Safety Data Sheet for Acetone. Product Number: 270725, Version 4.10 (Revision Date 11/24/2014). Available from, as of January 5, 2015: <http://www.sigmaaldrich.com/safety-center.html/>.
Protective equipment made from natural rubber, viton, neoprene, polyvinyl alcohol, neoprene/natural rubber, or nitrile have breakthrough times less (usually significantly less) than one hour reported by (normally) two or more testers.
ACGIH; Guidelines Select of Chem Protect Clothing Volume #1 Field Guide p.68 (1983).
Protective clothing made from polyethylene or chlorinated polyethylene; the data suggests breakthrough times of approximately an hour or more.
ACGIH; Guidelines Select of Chem Protect Clothing Volume #1 Field Guide p.68 (1983).
No data is available regarding break-through times for clothing made from styrene-butadiene rubber, nitrile/polyvinyl chloride, or polyurethane.
ACGIH; Guidelines Select of Chem Protect Clothing Volume #1 Field Guide p.68 (1983).
Wear appropriate eye protection to prevent eye contact.
NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: <http://www.cdc.gov/niosh/npg>.
Wear appropriate personal protective clothing to prevent skin contact.
NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: <http://www.cdc.gov/niosh/npg>.
Respirator Recommendations: Up to 2500 ppm:
Assigned Protection Factor (APF)
Respirator Recommendations
APF = 10
Any chemical cartridge respirator with organic vapor cartridge(s). Substance reported to cause eye irritation or damage; may require eye protection.
APF = 25
Any powered, air-purifying respirator with organic vapor cartridge(s). Substance reported to cause eye irritation or damage; may require eye protection.
APF = 50
Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister.
APF = 10
Any supplied-air respirator. Substance reported to cause eye irritation or damage; may require eye protection.
APF = 50
Any self-contained breathing apparatus with a full facepiece.
NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: <http://www.cdc.gov/niosh/npg>.
Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions:
Assigned Protection Factor (APF)
Respirator Recommendations
APF = 10,000
Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.
APF = 10,000
Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxillary self-contained positive-pressure breathing apparatus.
NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: <http://www.cdc.gov/niosh/npg>.
Respirator Recommendations: Escape:
Assigned Protection Factor (APF)
Respirator Recommendations
APF = 50
Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus.
NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: <http://www.cdc.gov/niosh/npg>.
Personnel protection: Wear appropriate chemical protective gloves, boots and goggles.
Association of American Railroads; Bureau of Explosives. Emergency Handling of Hazardous Materials in Surface Transportation. Association of American Railroads, Pueblo, CO. 2005. 4.