Chloroform

CAS RN: 67-66-3

Reactivities / Incompatibilities

Mixtures with dinitrogen tetraoxide are explosive when subjected to shock of 25 g TNT equiv or less.
Chloroform and acetone interact vigorously & exothermally in presence of solid potassium hydroxide or calcium hydroxide to form 1,1,1-trichloro-2-hydroxy-2-methylpropane. A laboratory incident involving the bursting of a solvent residues bottle was attributed to this reaction.
Heating aluminum powder with carbon tetrachloride-chloroform mixtures in closed systems to 152 deg C may cause an explosion, particularly if traces of aluminum chloride are present.
Triisopropylphosphine reacts, when undiluted, rather vigorously with chloroform.
Disilane ... reacts vigorously with incandescence in contact with chloroform.
Chloroform with various alkali metals is impact-sensitive as follows: weak explosion with lithium; fairly strong with sodium; strong with potassium; and violent with sodium-potassium.
A violent explosion occurs if a soln of perchloric acid in chloroform is poured on phosphorus pentoxide.
When chloroform or methyl chloride (or a mixture of both) contacts magnesium, an explosion occurs.
When 1 g of sodium hydroxide was added to a mixture of 1 mL methanol and 1 mL chloroform, an exothermic reaction occurred. Potassium hydroxide and other alkalies may replace sodium hydroxide as a reactant.
Incompatible with dinitrogen tetraoxide, fluorine, metals, or triisopropylphosphine.
Chloroform ... explodes when in contact with aluminum powder or magnesium powder.
Strong caustics; chemically-active metals such as aluminum or magnesium powder, sodium & potassium; strong oxidizers ... .
Explosive reaction with sodium + methanol or sodium methoxide + methanol. Mixtures with sodium or potassium are impact sensitive explosives.
The system, sodium plus chloroform, is shock sensitive, producing a fairly strong explosion.
A mixture of acetone and chloroform in a residue bottle exploded. Since addition of chloroform to acetone in the presence of a base will result in a highly exothermic reaction, it is thought that a base may have been in the bottle.
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