CAS RN: 463-82-1

Toxicity Summary

IDENTIFICATION AND USE: Dimethylpropane is a colorless flammable gas or a volatile liquid. It is used as a research chemical and in the manufacture of butyl rubber. HUMAN EXPOSURE AND TOXICITY: Drinking of dimethylpropane is expected to cause nausea, vomiting, stomach pain, and diarrhea. Dimethylpropane is expected to be a potential aspiration hazard when swallowed because of its low surface tension and low viscosity. Once in the respiratory system, it can lead to spasms of the bronchial system, edema and hemorrhaging, chemical pneumonitis, asphyxia, or death. Signs and symptoms include coughing, choking, and gasping. Dimethylpropane vapor is nontoxic when inhaled except at very high concentrations exceeding the lower flammability limit. When large quantities are inhaled, dimethylpropane acts as an anesthetic and asphyxiant. At these high levels it will cause CNS depression such as drowsiness, anesthesia, and at higher concentrations, coma and death. Repeated or prolonged contact with skin may cause dermatitis. No further studies on human exposure or toxicity could be located. ANIMAL STUDIES: Dimethylpropane caused light anesthesia in mice exposed to 200,000 ppm for 30 min and anesthesia (loss of posture) at 270,000 ppm for 3 min exposure. Dimethylpropane was lethal to 40% of the mice exposed for 2 hr at a concentration of 340,000 ppm. After 2 hr of anesthesia, the surviving mice recovered quickly on average in 4 min. Dimethylpropane is hydroxylated by rat liver microsomes to its parent alcohol 2,2-dimethylpropanol. No other animal studies could be located.
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