CAS RN: 505-60-2

Hazards Summary

The major hazards encountered in the use and handling of bis(2-chloroethyl)sulfide stem from its toxicologic properties. Toxic by all routes (ie, inhalation, ingestion, or dermal contact), exposure to this sweet-smelling, colorless, oily liquid may occur from its storage, transport, or use in organic synthesis. Effects from exposure occur from its severe irritant properties and may include blistering/necrosis of the skin, corneal ulceration/blindness, and pulmonary edema, all of which may be delayed in onset. Bis(2-chloroethyl)sulfide has been indicated as a human carcinogen (Group 1) by the International Agency for Research on Cancer (IARC). Exposure should be controlled by mechanical ventilation. In activities and situations where over-exposure may occur, wear appropriate chemical protective clothing and a positive pressure, self-contained breathing apparatus. If exposure should occur, immediately flush contaminated skin or eyes with water and neutralize with a 2.5 per cent solution of sodium thiosulfate. Contaminated clothing should be removed and discarded or left at the work site for cleaning before reuse. Smoking, eating, and drinking should be prohibited in bis(2-chloroethyl)sulfide, prolonged exposure to fire or heat may cause cylinders to violently rupture and rocket. For fires involving this substance, extinguish with dry chemical, CO2, foam, or water. Fight fire from as far a distance as possible. Bis(2-chloroethyl)sulfide should be stored in dry areas, away from heat, sources of ignition, and strong oxidizers. Spills of this substance should be prohibited from entering water sources and sewers. Before implementing land disposal of bis(2-chloroethyl)sulfide waste, consult with environmental regulatory agencies for guidance.
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