Tris(2-Chloroethyl)amine

CAS RN: 555-77-1

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) Tris(2-chloroethyl)amine is a potent nitrogen mustard compound which has been tested as a military chemical warfare agent. It is an irritant of the eyes, skin, and the respiratory and gastrointestinal tracts. Systemic absorption causes inhibition of cell mitosis, resulting in severe hemorrhagic diarrhea, necrotic lesions of the gastrointestinal mucosa, and bone marrow depression. Convulsions have been noted in exposed experimental animals only.
    • B) Eye exposure can cause severe irritation. Concentrations that do not cause skin or respiratory tract irritation can be extremely irritating to the eyes.
    • C) Dermal exposure to the liquid or vapor can cause erythema, pruritus, irritation, and delayed blister formation in erythematous areas.
    • D) Vapor inhalation can cause severe respiratory tract effects, beginning with irritation of the nose and throat. Cough, hoarseness, fever, difficulty in breathing, moist rales, and bronchial pneumonia may occur.
    • E) Ingestion can produce nausea and vomiting. Severe esophageal or gastrointestinal tract irritation may be predicted to occur following ingestion, based on this agent's other irritant properties.
0.2.3 VITAL SIGNS0.2.4 HEENT
  • 0.2.4.1 ACUTE EXPOSURE
    • A) Conjunctivitis, as well as nose and throat irritation, may be seen.
0.2.6 RESPIRATORY
  • 0.2.6.1 ACUTE EXPOSURE
    • A) Respiratory tract irritation and chemical pneumonitis may occur.
0.2.7 NEUROLOGIC
  • 0.2.7.1 ACUTE EXPOSURE
    • A) Convulsions have been noted in exposed experimental animals.
0.2.8 GASTROINTESTINAL
  • 0.2.8.1 ACUTE EXPOSURE
    • A) Ingestion can produce nausea and vomiting. Severe esophageal or gastrointestinal tract irritation may occur. Hemorrhagic diarrhea and intestinal mucosal sloughing may be seen.
0.2.13 HEMATOLOGIC
  • 0.2.13.1 ACUTE EXPOSURE
    • A) Bone marrow depression may occur.
0.2.14 DERMATOLOGIC
  • 0.2.14.1 ACUTE EXPOSURE
    • A) Dermal exposure to liquid or vapor can cause erythema, pruritus, irritation, and delayed blister formation.
0.2.20 REPRODUCTIVE HAZARDS
  • A) The hydrochloride salt inhibited spermatogenesis in mice at usual human therapeutic doses.
0.2.21 CARCINOGENICITY
  • 0.2.21.1 IARC CATEGORY
    • A) IARC Carcinogenicity Ratings for CAS555-77-1 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
      • 1) Not Listed
  • 0.2.21.3 ANIMAL OVERVIEW
    • A) This agent is considered carcinogenic by RTECS criteria.
0.2.22 GENOTOXICITY
  • A) As an alkylating agent, tris(2-chloroethyl)amine would be expected to be genotoxic. DNA inhibition was seen in mammalian cells. Mutations were noted in E. coli and hamster lung cells. Sex chromosome loss/nondisjunction was observed in D. melanogaster.
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