CAS RN: 555-77-1

Exposure Summary

The nitrogen mustards (including tris(2-chloroethyl)amine) are not manufactured in significant commercial quantities in the United States and they were never stockpiled as part of the U.S. chemical warfare inventory. Although several of the nitrogen mustards have medicinal uses as antineoplastic agents, tris(2-chloroethyl)amine does not appear to be currently used in the United States. If released to air, a vapor pressure of 0.011 mm Hg at 25 deg C indicates tris(2-chloroethyl)amine will exist solely in the vapor-phase in the ambient atmosphere. Vapor-phase tris(2-chloroethyl)amine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 1.5 days. If released to soil, tris(2-chloroethyl)amine is expected to have low mobility based upon an estimated Koc of 672. Tris(2-chloroethyl)amine has a pKa of 4.64 and is expected to exist in both the protonated form and neutral species in the ambient environment. At neutral to alkaline conditions, the neutral species will be the dominant form of tris(2-chloroethyl)amine, but under acidic conditions the protonated form may also exist. The protonated form of tris(2-chloroethyl)amine will adsorb to soil surfaces more than the neutral species. Volatilization of the neutral species from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 1.85X10-5 atm-cu m/mole. The protonated form of tris(2-chloroethyl)amine will not volatilize from water or moist soil surfaces. Tris(2-chloroethyl)amine is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Tris(2-chloroethyl)amine was reported to hydrolyze slowly for a nitrogen mustard, but under alkaline conditions approximately 90-95% degradation was observed after 24 hours. Therefore, hydrolysis will be an important fate process in moist soils and water surfaces. If released into water, tris(2-chloroethyl)amine is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization of the neutral species from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 47 hours and 26 days, respectively. An estimated BCF of 11 suggests the potential for bioconcentration in aquatic organisms is low, and hydrolysis should preclude bioconcentration from being a major fate process. Due to the high toxicity of this compound, strict safeguards are employed to control the release of tris(2-chloroethyl)amine. Therefore, the general population will not be exposed to this compound and occupational exposure via dermal and inhalation routes are not likely. (SRC)
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