Hydrogen peroxide

CAS RN: 7722-84-1

Range of Toxicity

A) TOXICITY: The toxic dose is not well defined. Sip ingestions of household products are not toxic, but large, deliberate ingestions may cause symptoms. Sip ingestions of concentrated products (more than 10% hydrogen peroxide) may cause gastrointestinal tract injury, oxygen embolization, or both. In one study, acute exposure to hydrogen peroxide vapors was mildly irritating to upper respiratory airways at 2.2 ppm, but not at 0.5 ppm.
B) Gastric ulcers developed in a young child who drank 2 to 4 ounces of 3% hydrogen peroxide.
C) It has been suggested (extrapolating from animal data) that a 10 kg infant may only need 2 mL/kg of gas (20 mL) to sustain a cardiac arrest; 3% hydrogen peroxide 2 mL can release 20 mL of oxygen microbubbles. Gas emboli secondary to irrigation with hydrogen peroxide has occurred during surgical procedures.
D) LIPID PEROXIDATION is the nonenzymatic oxidative destruction of fatty acids. Hydrogen peroxide may serve as a potential source of hydroxyl radical generation and lead to lipid peroxidation. Case reports of postmortem brain samples provide some evidence to support the occurrence of this process with unintentional IV infusion of 3% hydrogen peroxide.
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