Bromine

CAS RN: 7726-95-6

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) USES: Bromine is used in gold extraction, manufacture of pharmaceuticals, ethylene bromide, and dyes, fire retardants, and as sanitation preparations for swimming pools and cooling towers.
    • B) PHARMACOLOGY: As an alkaline corrosive, bromine may cause liquefaction necrosis. It can saponify the fats in the cell membrane, destroying the cell and allowing deep penetration into mucosal tissue. In gastrointestinal tissue, an initial inflammatory phase may be followed by tissue necrosis (sometimes resulting in perforation), then granulation and finally stricture formation.
    • C) EPIDEMIOLOGY: Although bromine is found in shock treatments for swimming pools and spas and is available for consumer use, exposure has been infrequently reported.
    • D) WITH POISONING/EXPOSURE
      • 1) Bromine exposure is unusual; limited data regarding specific human toxicity following bromine exposure is available. The following effects could be expected to occur, based on exposure data of other alkaline corrosives.
      • 2) MILD TO MODERATE ORAL TOXICITY: Patients with mild ingestions may only develop irritation or grade I (superficial hyperemia and edema) burns of the oropharynx, esophagus or stomach; acute or chronic complications are unlikely. Patients with moderate toxicity may develop grade II burns (superficial blisters, erosions and ulcerations) and are at risk for subsequent stricture formation, particularly esophageal. Some patients (particularly young children) may develop upper airway edema.
        • a) Alkaline corrosive ingestion may produce burns to the oropharynx, upper airway, esophagus and occasionally stomach. Spontaneous vomiting may occur. The absence of visible oral burns does NOT reliably exclude the presence of esophageal burns. The presence of stridor, vomiting, drooling, and abdominal pain are associated with serious esophageal injury in most cases.
        • b) PREDICTIVE: The grade of mucosal injury at endoscopy is the strongest predictive factor for the occurrence of systemic and GI complications and mortality.
      • 3) SEVERE ORAL TOXICITY: May develop deep burns and necrosis of the gastrointestinal mucosa. Complications often include perforation (esophageal, gastric, rarely duodenal), fistula formation (tracheoesophageal, aortoesophageal), and gastrointestinal bleeding. Upper airway edema is common and often life threatening. Hypotension, tachycardia, tachypnea and, rarely, fever may develop. Stricture formation (esophageal, less often oral or gastric) is likely to develop long term. Esophageal carcinoma is another long term complication. Severe toxicity is generally limited to deliberate ingestions in adults in the US, because alkaline products available in the home are generally of low concentration.
      • 4) INHALATION EXPOSURE: Mild exposure may cause cough and bronchospasm. Severe inhalation may cause upper airway edema and burns, stridor, and rarely acute lung injury.
      • 5) OCULAR EXPOSURE: Ocular exposure can produce severe conjunctival irritation and chemosis, corneal epithelial defects, limbal ischemia, permanent visual loss and in severe cases perforation.
      • 6) DERMAL EXPOSURE: Mild exposure causes irritation and partial thickness burns. Prolonged exposure or high concentration products can cause full thickness burns.
0.2.3 VITAL SIGNS
  • 0.2.3.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) Hypotension may occur after ingestion with corrosive injury and hemorrhage from the gastrointestinal tract.
0.2.4 HEENT
  • 0.2.4.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) Lacrimation, epistaxis, photophobia, blepharospasm, and brown discoloration of mucous membranes and the tongue may be noted.
0.2.5 CARDIOVASCULAR
  • 0.2.5.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) HYPOTENSION - Oral ingestion may result in shock secondary to corrosive effects.
0.2.6 RESPIRATORY
  • 0.2.6.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) Inhalation may cause severe irritation of the respiratory tract, cough, delayed pulmonary edema, bronchospasm, chemical pneumonitis, ARDS, glottal spasm, and glottal edema. Bromine is reported to be a more potent respiratory irritant than chlorine.
0.2.7 NEUROLOGIC
  • 0.2.7.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) Headache and dizziness have been reported.
0.2.8 GASTROINTESTINAL
  • 0.2.8.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) Following ingestion mucosal burns, esophagitis, and gastroenteritis have occurred.
      • 2) Diarrhea, nausea, vomiting, and abdominal pain have been reported following inhalation exposure.
0.2.10 GENITOURINARY
  • 0.2.10.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) Hemorrhagic nephritis, with oliguria or anuria, may develop within 1 to 2 days after oral ingestion of liquid bromine, as a sequelae to shock or hemolysis.
0.2.14 DERMATOLOGIC
  • 0.2.14.1 ACUTE EXPOSURE
    • A) WITH POISONING/EXPOSURE
      • 1) Dermatitis may occur following inhalation exposure.
      • 2) Dermal burns may be noted.
0.2.21 CARCINOGENICITY
  • 0.2.21.1 IARC CATEGORY
    • A) IARC Carcinogenicity Ratings for CAS7726-95-6 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004):
      • 1) Not Listed
  • 0.2.21.2 HUMAN OVERVIEW
    • A) No studies on the possible carcinogenic effects of bromine were found at the time of this review.
  • 0.2.21.3 ANIMAL OVERVIEW
    • A) No studies on the possible carcinogenic effects of bromine were found at the time of this review.
0.2.22 GENOTOXICITY
  • A) No studies on the possible genetic effects of bromine were found at the time of this review.
Find more information on this substance at: PubChem, PubMed