Nitrogen tetroxide

CAS RN: 10544-72-6

Health Effects

0.2.1 SUMMARY OF EXPOSURE
  • 0.2.1.1 ACUTE EXPOSURE
    • A) Exposure to nitrogen oxides is usually via inhalation and may result in acute or chronic changes of the pulmonary system including pulmonary edema, pneumonitis, bronchitis, bronchiolitis, fibrosing bronchiolitis, bronchiolitis obliterans, emphysema and possibly methemoglobinemia.
    • B) Exposure to low concentrations of nitrogen oxides usually results in mild and transient symptoms including a slight cough, fatigue and nausea. Very concentrated exposures may result in immediate coughing, choking, headache, nausea, abdominal pain and dyspnea.
    • C) Following exposure, there may be a latent period of 5 to 72 hours, before inflammation of the lungs develops causing exudation into alveolar spaces. Clinical deterioration may then occur.
0.2.3 VITAL SIGNS0.2.4 HEENT
  • 0.2.4.1 ACUTE EXPOSURE
    • A) Conjunctivitis may occur.
0.2.5 CARDIOVASCULAR
  • 0.2.5.1 ACUTE EXPOSURE
    • A) A weak rapid pulse and circulatory collapse may develop.
0.2.6 RESPIRATORY
  • 0.2.6.1 ACUTE EXPOSURE
    • A) Cough, hyperpnea and dyspnea may be seen. Rapid and shallow respirations, mild or violent coughing and physical signs of acute lung injury may develop. Acute lung injury may be delayed 4 to 24 hours.
    • B) Nitrogen dioxide can cause bronchospasm, and acute or chronic obstructive lung disease (after repeated/chronic exposure), and may increase susceptibility to respiratory virus infections.
0.2.7 NEUROLOGIC
  • 0.2.7.1 ACUTE EXPOSURE
    • A) Fatigue, restlessness, anxiety, mental confusion, lethargy, and loss of consciousness may be noted.
0.2.8 GASTROINTESTINAL
  • 0.2.8.1 ACUTE EXPOSURE
    • A) Nausea, vomiting and abdominal pain may develop.
0.2.13 HEMATOLOGIC
  • 0.2.13.1 ACUTE EXPOSURE
    • A) Methemoglobinemia may occur with nitric oxide exposures.
0.2.14 DERMATOLOGIC
  • 0.2.14.1 ACUTE EXPOSURE
    • A) Cyanosis may occur.
0.2.22 GENOTOXICITY
  • A) Chromosome aberrations and mutations in lung cells were evident in an in vivo animal study following inhalation of NO2 and NO. Negative results were obtained for chromosome aberrations in lymphocytes and spermatocytes or micronuclei in bone marrow after NO2 inhalation (Victorin, 1994).
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