Mechlorethamine

A) Mechlorethamine plasma concentrations are not clinically useful or readily available.
B) Monitor vital signs, serum electrolytes, renal function and liver enzymes in symptomatic patients.
C) Monitor serial CBC (with differential) and platelet count until there is evidence of bone marrow recovery.
D) Monitor for clinical evidence of infection, with particular attention to: odontogenic infection, oropharynx, esophagus, soft tissues particularly in the perirectal region, exit and tunnel sites of central venous access devices, upper and lower respiratory tracts, and urinary tract.
E) Clinically evaluate patients for the development of mucositis.
F) Monitor arterial blood gases and/or pulse oximetry, chest radiograph, and pulmonary function tests in patients with respiratory symptoms.