Methyl isobutyl ketone

CAS RN: 108-10-1

Range of Toxicity

A) TOXICITY: Minimal toxic doses of ketones are variable and not well defined. Airborne concentrations greater 300 ppm of methyl ethyl ketone may result in discomfort and CNS depression. Methyl-isobutyl ketone produces irritation at an airborne concentration of 100 ppm. Immediately Dangerous To Life or Health Concentrations (IDLHs): Ethyl butyl ketone: 1000 ppm; Methyl (n-amyl) ketone: 800 ppm; Diisobutyl ketone: 500 ppm. NIOSH Pocket Guide RELs: Diethyl ketone: 200 ppm (705 mg/m(3)) TWA; Diisobutyl ketone: 25 ppm (150 mg/m(3)) TWA; methyl isobutyl ketone: 50 ppm (205 mg/m(3)) ST 75 ppm (300 mg/m(3)). ACGIH-TLV: The 8 hour exposure limit TLV-TWA: Methyl isobutyl ketone: 20 ppm; diethyl ketone: 200 ppm; ethyl butyl ketone: 50 ppm (230 mg/m(3)); methyl propyl ketone: 150 ppm.
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