Nerve Agents

Pediatric Vulnerabilities

Pediatric

Pediatric/Obstetric/Geriatric Vulnerabilities

  • Nerve Agents may penetrate the blood brain barrier more easily in children than adults. Children may only exhibit CNS effects.
  • Children under four years of age with status epilepticus have the highest risk of death.
  • A child's smaller mass alone reduces the dose of nerve agent required for toxic/lethal effects. Animal studies have shown that the lethal dose of nerve agent in an immature vs. adult animal is 10 %.
  • With higher respiratory rates and minute volumes than adults a child will inhale a greater dose of nerve agent.
  • The smaller airway diameter, anatomic subglottic narrowing, omega shaped epiglottic structure, relatively large tongue size, less rigid ribs and trachea make them more vulnerable to nerve agent induces pathology i.e. bronchospasm, copious secretions.
  • There are few case reports regarding fetal toxicity from nerve agent/organophosphate exposure.
  • There is a high incidence of premature labor following organophosphate exposure in which maternal treatment has been delayed.
  • Link to Primary and Secondary Survey
Find more information on this substance at: PubChem, PubMed