CAS RN: 71195-58-9


A) Monitor vital signs frequently, pulse oximetry, and continuous cardiac monitoring.
B) Monitor for CNS and respiratory depression.
C) Opioid plasma levels are not clinically useful or readily available. Urine toxicology screens may confirm exposure, but are rarely useful in guiding therapy; urine toxicology immunoassays may also miss synthetic opioids (eg, fentanyl and methadone).
D) Obtain acetaminophen and salicylate levels in patients with a suspected overdose that may include combination products.
E) Routine lab work is usually not indicated, unless it is helpful to rule out other causes or if the diagnosis of opioid toxicity is uncertain.
F) Obtain a chest x-ray for persistent hypoxia. Consider a head CT and/or lumbar puncture to rule out an intracranial mass, bleeding or infection, if the diagnosis is uncertain.
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