Alfentanil

CAS RN: 71195-58-9

Exposure Summary

Alfentanil's production and use as a narcotic analgesic may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.4X10-11 mm Hg at 25 deg C indicates alfentanil will exist solely in the particulate phase in the atmosphere. Particulate-phase alfentanil will be removed from the atmosphere by wet and dry deposition. Alfentanil contains chromophores that absorb at wavelengths >290 nm and, therefore, may be susceptible to direct photolysis by sunlight. If released to soil, alfentanil is expected to have low mobility based upon an estimated Koc of 680. The pKa of alfentanil is 6.5, indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon the pKa and an estimated Henry's Law constant of 9.7X10-20 atm-cu m/mole. Alfentanil is not expected to volatilize from dry soil surfaces based upon its estimated vapor pressure. Biodegradation data in soil or water were not available. If released into water, alfentanil is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated pKa and Henry's Law constant. An estimated BCF of 12 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to alfentanil may occur through dermal contact with this compound at workplaces where alfentanil is produced or administered. Exposure to alfentanil among the general population may be limited to those administered the drug or its use as an illicit drug. (SRC)
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