Sufentanil

CAS RN: 56030-54-7

Exposure Summary

Sufentanil's production and administration as a pain medicine may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.9X10-9 mm Hg at 25 deg C indicates sufentanil will exist solely in the particulate phase in the atmosphere. Particulate-phase sufentanil will be removed from the atmosphere by wet and dry deposition. Sufentanil contains chromophores that absorb at wavelengths >290 nm and, therefore, may be susceptible to direct photolysis by sunlight. If released to soil, sufentanil is expected to have no mobility based upon an estimated Koc of 16,000. The pKa of sufentanil is 8.01, indicating that this compound will exist partially in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon its pKa and an estimated Henry's Law constant of 7.8X10-14 atm-cu m/mole. Sufentanil is not expected to volatilize from dry soil surfaces based upon its estimated vapor pressure. Biodegradation data in soil or water were not available. If released into water, sufentanil is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's pKa and estimated Henry's Law constant. An estimated BCF of 190 suggests the potential for bioconcentration in aquatic organisms is high. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to sufentanil may occur through dermal contact with this compound at workplaces where sufentanil is produced or administered. Exposure to sufentanil among the general population may be limited to those administered the drug or its use as an illicit drug. (SRC)
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