CAS RN: 77-10-1

Range of Toxicity

A) TOXICITY: Symptoms are expected at doses of approximately 0.05 to 0.1 mg/kg. A dose of 1 to 5 mg will normally result in euphoria and numbness, resembling ethanol intoxication. Doses of 5 to 10 mg often result in excitation, confusion, ataxia, and dysarthria. Prolonged coma, seizures, and death may result from 20 mg or more. Fatalities are more often related to trauma than to direct drug effects.
B) Blood levels of 20 to 30 ng/mL may cause excitation and catatonia; 30 to 100 ng/mL may cause coma and myoclonus; above 100 ng/mL may cause seizures and hypotension.
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