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Non-Human Toxicity Values
LD50 Rat (male) oral 330 mg/kg /From table/
USEPA/OPPTS; Revised Ethylene Oxide HED Risk Assessment for Reregistration Eligibility Document (RED) p.11 EPA-HQ-OPP-2005-0203-0100 (May 2007). Available from, as of July 21, 2008: <http://www.regulations.gov/search/Regs/home.html#home/>.
LD50 Rat oral 72 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 41 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LD50 Mouse male oral 280 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 42 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LD50 Mouse female oral 365 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 43 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LD50 Guinea pig oral 270 mg/kg
ITII. Toxic and Hazardous Industrial Chemicals Safety Manual. Tokyo, Japan: The International Technical Information Institute, 1988. 237.
LC50 Rat inhalation 1462 ppm/4 hr (2.63 mg/L)
ITII. Toxic and Hazardous Industrial Chemicals Safety Manual. Tokyo, Japan: The International Technical Information Institute, 1988. 237.
LC50 Rat inhalation 1.44 mg/L/4hr
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 44 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LC50 Rat inhalation 0.9 mg/L/1 hr
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 45 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LC50 Rat inhalation 1.59-4.14 mg/L/4 hr
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 45 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LC50 Rat inhalation 5029 ppm (9.2 mg/L)/1 hr /From table/
USEPA/OPPTS; Revised Ethylene Oxide HED Risk Assessment for Reregistration Eligibility Document (RED) p.11 EPA-HQ-OPP-2005-0203-0100 (May 2007). Available from, as of July 21, 2008: <http://www.regulations.gov/search/Regs/home.html#home/>.
LC50 Mouse inhalation 836 ppm/4 hr (1.505 mg/L)
ITII. Toxic and Hazardous Industrial Chemicals Safety Manual. Tokyo, Japan: The International Technical Information Institute, 1988. 237.
LC50 Guinea pig inhalation 1.5 mg/L/4 hr
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 49 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LC50 Dog inhalation 973 ppm/4 hr
ITII. Toxic and Hazardous Industrial Chemicals Safety Manual. Tokyo, Japan: The International Technical Information Institute, 1988. 237.
LC50 Dog inhalation 983 ppm (1.8 mg/L)/4 hr /From table/
USEPA/OPPTS; Revised Ethylene Oxide HED Risk Assessment for Reregistration Eligibility Document (RED) p.11 EPA-HQ-OPP-2005-0203-0100 (May 2007). Available from, as of July 21, 2008: <http://www.regulations.gov/search/Regs/home.html#home/>.
LD50 Rat intraperitoneal 100 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 54 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LD50 Mouse intraperitoneal 175 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 55 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LD50 Rat subcutaneous 187 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 55 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LD50 Rat intravenous 290 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 55 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
LD50 Mouse intravenous 290 mg/kg bw
European Chemicals Bureau; IUCLID Dataset, Ethylene Oxide (CAS # 75-21-8) p. 56 (2000 CD-ROM edition). Available from, as of July 9, 2008: <http://esis.jrc.ec.europa.eu/>.
