CAS RN: 537-46-2

Range of Toxicity

A) TOXICITY: Dose response is variable. In adults, the acute lethal dose of amphetamine has been reported to be 20 to 25 mg/kg. Patients who chronically abuse amphetamines develop tolerance, and up to 15,000 mg/day has been ingested without lethal result.
B) THERAPEUTIC DOSE: ADULT: Amphetamine: 5 to 60 mg/day in divided doses for narcolepsy or 20 mg daily as an extended-release tablet for the treatment of adult ADHD; Benzphetamine: 25 to 50 mg 1 to 3 times daily; Diethylpropion: 75 mg/day; Lisdexamfetamine: 30 to 70 mg once daily; Phendimetrazine: 35 mg two to three times daily or 105 mg as a sustained-release capsule once daily; Phentermine: 18.75 or 37.5 mg once daily. PEDIATRIC: Amphetamine (6 years and older): 5 mg once or twice daily; rare for dose to exceed 40 mg/day for ADHD, or 10 mg extended-release capsule once daily not to exceed 30 mg daily for ADHD; Lisdexamfetamine (6 to 17 years of age): Initially 30 mg once daily, up to a maximum dose of 70 mg once daily for the treatment of ADHD.
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