Fourth Generation Agents

Medical Management


Medical Management Overview

  • FGAs are more persistent than and at least as potent as other nerve agents. FGAs may require more aggressive supportive care, greater amounts of medication, and a longer duration of treatment.
  • Along with supportive care and patient decontamination, the mainstays of managing nerve agent toxicity, including FGA toxicity, are anticholinergics (e.g., atropine), oxime AChE reactivators (e.g., pralidoxime chloride, or 2-PAM), and anticonvulsants (e.g., the benzodiazepines - diazepam, midazolam, and lorazepam).
  • See the FGA Medical Management Guidelines (Fourth Generation Agents) for detailed information on treatment.
Find more information on this substance at: PubChem, PubMed