Phosgene

CAS RN: 75-44-5

Differential Diagnosis

Question Mark

Differential Diagnosis

  • Since phosgene is a respiratory tract irritant, but has unique toxicological concerns due to the latency of onset of pulmonary edema, differentiating it from the typical presentation of symptoms from other common chemical irritants is an important consideration.
  • Phosgene is distinguished by its smell in high concentrations and delayed onset of pulmonary edema.
  • Chlorine has a characteristic odor even in low concentrations, immediate onset of respiratory distress, bronchospasm, eye, skin, and upper airway irritation.
  • Riot agents cause an acute onset of burning sensation in the eyes and upper airway without progression of symptoms with ongoing exposures.
  • Nerve agents induce watery secretions as well as respiratory distress, but have a host of other symptoms, such as miosis, seizures, rapidity of onset, that can distinguish them from pulmonary agents.
  • The respiratory toxicity of vesicants (i.e. Mustard Gas) is usually delayed, but affects the central rather than the peripheral airway. Vesicant toxicity severe enough to cause dyspnea typically causes airway necrosis often with upper airway obstruction.
  • Link to Chemical Hazards Emergency Medical Management Intelligent Syndromes Tool (CHEMM-IST)
Find more information on this substance at: PubChem, PubMed